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The active constituents of Euthasol Solution include sodium pentobarbital and sodium phenytoin. It is a non-sterile solution. The inclusion of bluish-red fluorescent pigment rhodamine B in the formulation helps set it apart from parenteral medications meant for therapeutic usage. Benzyl alcohol, a bacteriostat, is added to the solution to slow down the growth of bacteria even though it is not sterile.
In every milliliter:
390 mg of pentobarbital sodium (a derivative of barbiturate acid), and 50 mg of phenytoin sodium are the active ingredients. The inactive ingredients are 10% ethyl alcohol, 18% propylene glycol, 0.003688 mg of rhodamine B, 2% benzyl alcohol (a preservative), and water for injection as needed. To change pH, add sodium hydroxide or hydrochloric acid.
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After intravenous administration of EUTHASOL Euthanasia Solution, the same series of events occurs that lead to humane, painless, and swift euthanasia as after intravenous injection of pentobarbital sodium or other derivatives of barbituric acid. In a matter of seconds, the dog simultaneously collapses and becomes unconscious. This phase quickly advances to profound anesthesia and lowers blood pressure at the same time. Shortly after, the medullary respiratory center depresses, causing breathing to stop; encephalographic activity to become isoelectric, signifying cerebral death; and finally, cardiac activity to halt.
During the deep anesthetic phase brought on by pentobarbital sodium, phenytoin sodium works. This substance speeds up the heart’s electrical activity cessation because of its cardiotoxic effects.
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