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Barbiturates are nonselective depressants of the central nervous system that are mostly utilized as sedative-hypnotics and, in subhypnotic dosages, as anticonvulsants. The Federal Controlled Substances Act regulates barbiturates and their sodium counterparts (see the section on “Drug Abuse and Dependence”).
Sterile parenteral solutions of amobarbital, pentobarbital, phenobarbital, and secobarbital sodium salts are available.
Barbituric acid, a chemical that has no action on the central nervous system (CNS), is the basic structure shared by barbiturates, which are substituted pyrimidine derivatives. Alkyl, alkenyl, or aryl groups can be substituted on the pyrimidine ring to produce CNS action.
Pentobarbital sodium injection, also known as NEMBUTAL Sodium Solution, is a sterile intravenous or intramuscular injectable solution. Pentobarbital sodium 50 milligrams per milliliter is included in a vehicle.
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